Astaxanthin molecular targets
Methods: PharmMapper database was used to retrieve the targets of natural astaxanthin, and TCGA database was used to identify the .
Nrf2 a molecular therapeutic target for Astaxanthin
S3 AST targets and inflammatory targets.This review provides an overview of the current knowledge on the anticancer potential of astaxanthin by modulating several molecular targets. In the present review, we discuss the role of Nrf2 in mediating the anti-cancer .
Abstract In order to further explore the potential pharmacological activity of astaxanthin (AST), network pharmacological approaches were employed in this work to systematically investigate its aff. Volume 137, May 2021, 111374. Advanced Search Citation Search.Molecular docking experiments confirmed that AST can form stable binding to several key nodes (SRD5A2, STS, AKR1C2, HSD11B1, and CYP17A1) in steroid .Eight week-supplementation of astaxanthin in humans resulted in increased blood levels of astaxanthin and improved activity of natural killer cells which targeted and destroyed cells infected with viruses. In detail, natural astaxanthin (3S, 3′S) is more than 90% esterified, while the synthetic version is all free form, or unesterified.Astaxanthin can affect molecular pathways involved in the homeostasis, through the activation of FOXO3-related genetic pathways, growth, and regeneration of . While it has been clearly demonstrated its multitarget activity in the prevention and regression of malignant cells in in vitro or in preclinical investigations, further clinical studies are needed to assess its real .Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging - PMC.There is currently much interest in biological active compounds derived from natural resources, especially compounds that can efficiently act on molecular targets, which are involved in various diseases. Due to its unique molecular features, AST has an excellent antioxidant activity with a wide range of applications in the nutraceutical and pharmaceutical industries. S5 The expression of TNF-α, STAT3 and NF-κB mRNA levels after the interference of TNF- 31 α siRNA 32 Table S1 PCR primer sequences.Auteur : Zhen Lin, Fangping Li, Yu Zhang, Xiaohui Tan, Ping Luo, Huazhong Liu It accumulates up to 3. The present review highlights the neuroprotective effects of AST .Targeted delivery of AST to specific regions of the gastrointestinal tract, or more selectively to target tissues and cells, can be achieved using targeted delivery systems . Astaxanthin (3,3′-dihydroxy-β, β′-carotene-4,4′-dione) is a xanthophyll carotenoid, contained in Haematococcus pluvialis, Chlorella zofingiensis, . More importantly, the molecular targets of AST were the most significantly associated with endometriosis. Zhen Lin, Fangping Li, +3 authors. 34 Table S3 Binding .Astaxanthin, a carotenoid of the xanthophyll group, has potent antioxidant properties due to its molecular structure and its arrangement in the plasma membrane, . Astaxanthin (3,3′-dihydroxy-β, β′-carotene-4,4′-dione) is a xanthophyll carotenoid, contained in Haematococcus pluvialis, Chlorella zofingiensis, Chlorococcum, and Phaffia rhodozyma.
Three underlying molecular targets (CSS1, YBR012W-B and DAN4) associated with astaxanthin biosynthesis were first uncovered by comparative genomics analysis. Here, ASX stabilizes membranes and acts as . While it has been clearly . AST has several favourable biological and pharmacological activities such . S4 Molecular docking analysis and molecular dynamics simulation of AST-TNF-α.Astaxanthin targets PI3K/Akt signaling pathway toward potential therapeutic applications.6% improvement on astaxanthin yield achieved by ARTP mutagenesis, indicating CSS1 was a very promising molecular ., 2019), while other direct targets for astaxanthin in different pathways remain elusive. In the past decade, mounting evidence has suggested a protective role for . Astaxanthin and Nrf2 Signaling Pathway: A . Thus far, astaxanthin has only been shown to directly interact with p38 MAPK (Yang et al.Nrf2 a molecular therapeutic target for Astaxanthin - ScienceDirect.Astaxanthin from Haematococcus pluvialis ameliorates the chemotherapeutic drug (doxorubicin) induced liver injury through the Keap1/Nrf2/HO-1 pathway in mice. Astaxanthin diester (Asta-DE) was better .In addition, utilizing network pharmacology and in silico calculations based on molecular docking, molecular dynamics simulation, we identified interleukin-6 (IL-6) . It has significant effects on the metabolism of many animals, increasing fecundity, egg yolk volume, growth rates, immune responses, and disease resistance. In a study by Ohgami and coauthors, astaxanthin suppressed the development of experimentally induced uveitis in a dose-dependent fashion. Astaxanthin (ATX) is a red pigment carotenoid present in shrimp, salmon, crab, and asteroidean. Affiliation 1 Research Institute of .natural resources, especially compounds that can efficiently act on molecular targets, which are involved in various diseases. Food and chemical toxicology: an international journal .In conclusion, although further studies are needed to better understand the precise molecular targets activated, astaxanthin is proposed as a non-pharmacological . Astaxanthin anticancer effects are .Astaxanthin (3,3′‐dihydroxy‐β,β‐carotene‐4,4′‐dione) is a keto‐carotenoid with a wide variety of health‐promoting properties through its effects on a plethora of molecular targets (Fakhri, Yosifova Aneva, Farzaei, & Sobarzo‐Sánchez, 2019). Functionally, grouped analysis of key . Skip to Article Content; Skip to Article Information; Search within. In order to further explore the potential pharmacological activity of astaxanthin (AST), network pharmacological approaches were employed in this work to . In summary, astaxanthin is currently only used as a food .A large part of the bioactivity of ASX is due to its targeting of mitochondria, where it inserts itself into cell membranes. To be noted, individual deletion of CSS1 can recover 75. A large part of the bioactivity of ASX is due to its targeting of mitochondria, where it inserts .111714 Corpus ID: 221466892; Astaxanthin targets PI3K/Akt signaling pathway toward potential therapeutic applications. 2010 Jun;13(3):548-56. @article{Zarneshan2020AstaxanthinTP, title={Astaxanthin targets PI3K/Akt signaling pathway toward potential therapeutic applications.Astaxanthin (3,3′-dihydroxy-β,β-carotene-4,4′-dione) is an orange-red, lipophilic keto-carotenoid pigment. Functionally, grouped analysis of key therapeutic nodes was carried out by establishing the interaction network between drug targets and disease targets.In Jin’s study, astaxanthin yield was improved by 0.1 mg/g DCW) via ARTP mutagenesis, which is the highest reported yield at shake-flask level in yeast so far.Actually, this production process leads to a mixture of astaxanthin isomers, which conferee important molecular and biological differences with respect to the natural carotenoid. pluvialis genetic transformation, and use of phytohormones that increase the gene expression related to astaxanthin biosynthesis and proposes future approaches, including cloning and characterization of transcription factors. 33 Table S2 Partial core target attributes.
While exerting inflammatory effects, the regulation of estrogen and other .
This review critically reviewed the studies on identifying transcription factors, progress in H. It is majorly found in marine ecosystems particularly in aquatic animals such as . More importantly, the molecular targets of AST were the most significantly associated .In this regard, astaxanthin (AST) has gained growing interest as a multi-target pharmacological agent against neurological disorders including Parkinson’s disease (PD), Alzheimer’s disease (AD), brain and spinal cord injuries, neuropathic pain (NP), aging, depression, and autism.
Analysis of astaxanthin molecular targets based on network
Three underlying molecular targets (CSS1, YBR012W-B and DAN4) associated with astaxanthin biosynthesis were first uncovered by comparative genomics analysis.More importantly, the molecular targets of AST were the most significantly associated with endometriosis.These oxidative products in turn enhance the inflammatory cascade by means of NF-κB activation and together alter cellular and molecular targets, destroying normal tissue homeostasis [51,52].In this review, we have described the effects of ATX on cancer as well as some molecular targets of ATX involved in cancer-associated processes (such as . Oxid Med Cell Longev. Microalgae are the .Analysis of astaxanthin molecular targets based on network pharmacological strategies.Astaxanthin (AST) is a naturally occurring compound isolated from various sources such as fungi, plants, salmon, and crab.83-fold over the engineered yeast strain through single ARTP treatment and three underlying molecular targets associated with astaxanthin biosynthesis in yeast were uncovered [15].Molecular docking experiments confirmed that AST can form stable binding to several key nodes (SRD5A2, STS, AKR1C2, HSD11B1, and . This chemical feature of the natural .Auteur : Zhen Lin, Fangping Li, Yu Zhang, Xiaohui Tan, Ping Luo, Huazhong Liu
Multiple Mechanisms of Anti-Cancer Effects Exerted by Astaxanthin
Functionally, grouped analysis of key therapeutic nodes .
[Therapeutic mechanism of natural astaxanthin against renal
Accumulating evidence indicates that astaxanthin exerts its beneficial effects against DM by acting on various molecular targets and signaling pathways in multiple .The results demonstrated that Asta-E with long-chain and saturated fatty acids were more stable than other types of Asta-E.
Among them, astaxanthin (AST), a potent carotenoid antioxidant, remains relatively underexplored regarding its anti-inflammatory mechanisms and specific molecular targets.In this regard, astaxanthin (AST) has gained growing interest as a multi-target pharmacological agent against neurological disorders including Parkinson’s .Objective: To explore the molecular mechanism by which natural astaxanthin (AST) inhibits renal clear cell carcinoma (KIRC) based on network pharmacology and bioinformatics.
