Bcor internal tandem duplication
The Journal of Molecular Diagnostics.
We identified internal tandem duplications in the BCOR gene (BCL6 corepressor) affecting the C terminus in 100% (20/20) of CCSK tumors but in none (0/1 .The central nervous system tumor with BCOR internal tandem duplication (CNS tumor with BCOR ITD) is a recently identified rare tumor entity, the complete morphologic .CNS tumor with BCOR internal tandem duplication (BCOR-ITD) is a rare and relatively new brain tumor type that has been added to the WHO classification of CNS tumors 5 th edition as part of the embryonal family of tumors.Recently, internal tandem duplication (ITD) of BCOR has been recognized as a genetic hallmark of CCSK.ITD in the last exon of BCOR is recurrent in all CCSK samples analyzed, representing a valuable molecular marker to improve diagnosis of this rare childhood renal tumor.
CNS tumour with BCOR internal tandem duplication
It is histologically characterized by a solid pattern with spindle-shaped cells and a dense capillary network.
BCOR internal tandem duplications (ITDs) and rearrangements are implicated in the oncogenesis of a subset of undifferentiated sarcomas.Here we report on the identification of somatic internal tandem duplications (ITDs) clustering in the C terminus of BCOR in 23 of 27 (85%) pediatric clear cell sarcomas of the kidney (CCSK) from .Pathology Outlines - High grade endometrial stromal sarcoma13 déc.Recently, a new group of CNS tumors characterized by a genetic BCL6 corepressor (BCOR) alteration and distinct histopathologic and clinical features was identified.Most CCSK are characterized by BCOR exon 16 internal tandem duplications (ITD), while a smaller subset shows YWHAE - NUTM2B/E fusions.
Internal tandem duplication within the BCOR gene sequence that encodes the PUFD domain, important in the formation of the non-canonical or variant polycomb repressor complex 1 (v-PRC1), was very recently described in 100% of 20 clear cell sarcomas of kidney (CCSKs). In pediatric cancers, BCOR ITDs have recurrently been described in clear cell sarcoma of kidney (CCSK), primitive myxoid mesenchymal tumor of infancy (PMMTI), and central .3390/ijms22083913. We investigated the presence of BCOR ITD by targeted sequencing in a series of 31 uterine sarcomas, comprising 5 low-grade ESS, 13 uterine sarcomas diagnosed as HG .Clear cell sarcoma of the kidney (CCSK) is the second most common pediatric renal tumor. Ferris SP, Velazquez Vega J, Aboian M, Lee JC, Van Ziffle J, Onodera C, Grenert JP, Saunders T, Chen YY, Banerjee A, Kline CN (2020) High-grade neuroepithelial tumor with BCOR exon 15 internal tandem duplication—a . Central nervous system tumor with BCL6-corepressor internal tandem duplication (CNS .Clear cell sarcoma of the kidney (CCSK) is the second most common pediatric renal malignancy, characterized by BCOR internal tandem duplication (ITD), YWHAE rearrangement, BCOR-CCNB3 fusion, and lack of other consistent structural alteration. 2020Pathology Outlines - Transducin-like enhancer of split 1 (TLE1) Afficher plus de résultats4 and encodes for an ubiquitously expressed nuclear protein involved in transcriptional regulation of BCL6 and of class I .While BCOR exon 15 internal tandem duplication was the solitary pathogenic alteration identified in six cases, four cases contained additional alterations .We identified internal tandem duplications in the BCOR gene (BCL6 corepressor) affecting the C terminus in 100% (20/20) of CCSK tumors but in none . Clear cell sarcoma of the kidney (CCSK) is the second most common pediatric renal malignancy, characterized by BCOR internal tandem .We collected a cohort of 13 ESS harboring variant alteration involving BCOR (6 with internal tandem duplication, 1 with EP300::BCOR fusion, 1 with BCOR::LPP fusion) and BCORL1 ( 4 with JAZF1::BCORL1 fusion, 1 with EPC1::BCORL1 fusion). Histopathologic examination of the tumor showed a moderately cellular tumor . The BCOR (BCL6 corepressor) gene is located on chromosome Xp11. Two recurrent genetic aberrations have been described in CCSK.
Recurrent internal tandem duplications of BCOR in clear cell
2015 Dec 1;6(38):40934 .The Central Nervous System (CNS) tumor with BCOR internal tandem duplication (ITD) has recently been added as a novel embryonal histomolecular tumor type to the 2021 World Health Organization (WHO) Classification of CNS Tumors. None of those 20 cases bore the YWHAE-NUTM2 transcript, previously . One is a fusion of YWHAE and NUTM2B/E, the other is an internal tandem duplication (ITD) in the BCOR gene.The central nervous system tumor with BCL-6 interacting corepressor internal tandem duplication (BCOR-ITD) is a molecularly defined entity with an internal tandem duplication in exon 15 of the BCOR gene.Only very recently new molecular features emerged, as the internal tandem duplication of BCOR , and the recurrent hypermethylation of TCF21 .High‐grade neuroepithelial tumor with BCOR exon 15 internal tandem duplication (HGNET BCOR ex15 ITD) is a recently proposed tumor entity of the central nervous system (CNS) with a distinct . Clear cell sarcoma of the kidney (CCSK) is the second most common pediatric renal malignancy, characterized by BCOR internal tandem duplication (ITD), YWHAE .BCOR immunohistochemistry can be used diagnostically to separate tumors with BCOR gene alteration (rearrangement or internal tandem duplication) from their .PMCID: PMC8070097.The majority of CCSKs have internal tandem duplications (ITDs) of the BCOR gene, whereas a minority have the YWHAE-NUTM2 gene fusion. The aim of this study was to characterise 11 histologically diagnosed CCSKs .the BCOR internal tandem duplication using targeted polymerase chain reaction for the duplicated region of BCOR (exon 15) on DNA extracted from formalin-fixed paraffin-embedded tumor tissue. In pediatric cancers, BCOR ITDs have recurrently been described in clear cell sarcoma of kidney (CCSK), primitive myxoid mesenc .Their genetic characteristic is a somatic internal tandem duplication in the 3' end of BCOR (BCOR ITD), which has also been found in clear cell sarcomas of the kidney (CCSK) and soft tissue undifferentiated round cell sarcomas/primitive myxoid mesenchymal tumors of infancy (URCS/PMMTI), and these BCOR ITD-positive tumors have been reported to .
The median patient age at primary diagnosis was 51 years (range: 18 to 70 y).Clear cell sarcoma of the kidney (CCSK) and primitive myxoid mesenchymal tumour of infancy (PMMTI) are paediatric sarcomas that most commonly harbour internal tandem duplications (ITDs) of exon 15 of the BCOR gene, in the range of 87–114 base pairs (bp).Central nervous system tumor with BCL6-corepressor internal tandem duplication (CNS-BCOR ITD) is a malignant entity characterized by recurrent alterations .Assessment of BCOR Internal Tandem Duplications in Pediatric Cancers by Targeted RNA Sequencing - ScienceDirect.BCOR-CCNB3 fusion and BCOR internal tandem duplication in undifferentiated round cell sarcoma: a pathologic and molecular study of 5 cases - PMC.While BCOR exon 15 internal tandem duplication was the solitary pathogenic alteration identified in six cases, four cases contained additional alterations including CDKN2A/B homozygous deletion, TERT amplification or promoter hotspot mutation, and damaging mutations in TP53, BCORL1, EP300, SMARCA2 and STAG2.
BCOR Internal Tandem Duplication in High-grade Uterine Sarcomas
Consistent in-frame internal tandem duplications of BCOR
1 CNS tumors with an internal tandem duplication (ITD) of the BCOR gene, formerly included in the group of primitive neuroectodermal tumors of the CNS, form a .
Some cases, instead, have BCOR-CCNB3 or YWHAE-NUTM2 gene fusions. Histopathologic examination of the tumor showed a .
Preoperative diagnosis of clear cell sarcoma of the kidney by
We accidentally identified TP53 deletion in CCSK, which was often associated with adverse .
BCOR Positive Central Nervous System Neuroepithelial Tumor
Very few cases of this .
A third 'double-negative' (DN) category comprises CCSKs with neither BCOR ITDs nor YWHAE-NUTM2 fusion. Kahlert, Jarek Maciaczyk, Eric H.Genomic alterations of BCOR via ZC3H7B-BCOR fusion or BCOR internal tandem duplication (ITD) define a subset of endometrial stromal sarcoma (ESS). Childs Nerv Syst 36(8):1589–1599 3. To date, BCOR ITD sarcomas have been exclusively found in non-appendicular infantile soft tissues, whereas BCOR-rearranged sarcomas occur in both bones and soft tissues affecting a wider patient age .CNS tumor with BCOR internal tandem duplication is a recently proposed malignant tumor.lial tumor with BCOR alteration (CNS HGNET-BCOR)—case-based reviews. The authors introduce an exemplary case and discuss the . In addition, other CNS tumors harboring a BCOR/BCORL1 fusion, which are defined by a distinct . The patient was an 18-month-old boy with torticollis and vomiting due to cerebellar hemispheric mass with extension to cerebellopontine angle and foramen magnum.Internal tandem duplication of B-cell CLL/lymphoma 6 ( BCL6 )-interacting co-repressor ( BCOR) exon 15 has recently been described in clear cell sarcoma of kidney, central nervous system.While BCOR exon 15 internal tandem duplication was the solitary pathogenic alteration identified in six cases, four cases contained additional alterations including CDKN2A/B homozygous deletion, TERT . Whole transcriptome sequencing identifies BCOR internal tandem duplication as a common feature of clear cell sarcoma of the kidney Oncotarget. Antonescu, Yu Chien Kao, Bin Xu, Yumi Fujisawa, Catherine Chung, Christopher D.Clear cell sarcoma of the kidney (CCSK) is one of the major pediatric renal neoplasms, but its associated genetic abnormalities are largely unknown.CNS tumor with BCOR internal tandem duplication (ITD) is a recently defined malignant tumor.
